期刊
CHEMISTRY CENTRAL JOURNAL
卷 6, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1752-153X-6-43
关键词
Launaea procumbens; Scavenging of DPPH-free radicals; Superoxide radicals; HPLC; Flavonoids
Background: Launaea procumbens (LP) has been used as a food supplement in Pakistan. In this study methanolic crude extract (LPME) of the whole plant and its different fractions; n-hexane (LPHE); ethyl acetate (LPEE) and chloroform (LPCE) were studied for the determination of total flavonoid and phenolics contents along with multifaceted in vitro scavenging assays. Results: Considerable amount of flavonoid and phenolics contents were found in all the fractions. Methanol and chloroform fraction exhibited efficient scavenging of DPPH center dot, ABTS center dot+, center dot OH, superoxide, lipid peroxide and nitric oxide free radicals. Significant correlation was found between DPPH., ABTS center dot+, superoxide radical, beta-carotene bleaching restraint and phosphomolybdenum assay with total flavonoids and phenolics contents. High performance chromatography (HPLC) of LPME revealed the presence of vitexin, orientin, rutin, hyperoside, catechin and myricetin. Conclusion: These results reveal the presence of bioactive compounds in LPME, which might be contributed towards the various in vitro scavenging.
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