期刊
CHEMISTRY CENTRAL JOURNAL
卷 6, 期 -, 页码 -出版社
SPRINGEROPEN
DOI: 10.1186/1752-153X-6-138
关键词
Oral bioavailability; Bioaccessibility; Lead [Pb] particles; In vivo tests; In vitro tests
资金
- Canadian Water Network
- Natural Sciences and Engineering Research Council (NSERC)
- Canada Industrial Chair on Drinking Water, the City of Montreal
- Canada Industrial Chair on Drinking Water, City of Ville Laval
- Canada Industrial Chair on Drinking Water, City of JMI-Veolia
In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
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