期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 179, 期 -, 页码 11-16出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2013.10.001
关键词
Cardiolipin; Heart failure; Thyroid hormone; Barth Syndrome; Metabolism; Diabetes; Lipid; Phospholipid; Mitochondria; Genetic disease
资金
- Heart and Stroke Foundation of Manitoba
- Canadian Institutes of Health Research
- Barth Syndrome Foundation
Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis and provide an overview of regulation of cardiolipin biosynthesis. In addition, the important role that this key phospholipid plays in disease processes including heart failure, diabetes, thyroid hormone disease and the genetic disease Barth Syndrome will be discussed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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