期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 184, 期 -, 页码 82-104出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2014.10.004
关键词
Lipid raft; Membrane protein; Peptide; Receptor; Membrane domain; Molecular dynamics simulations; Coarse-grained simulations
资金
- Academy of Finland
- Center of Excellence grant
- Sigrid Juselius Foundation
- European Research Council Advanced Grant CROWDED-PRO-LIPIDS
Lipids rafts are considered to be functional nanoscale membrane domains enriched in cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell membranes. Lipids, together with membrane-associated proteins, are therefore considered to form nanoscale units with potential specific functions. Although the understanding of the structure of rafts in living cells is quite limited, the possible functions of rafts are widely discussed in the literature, highlighting their importance in cellular functions. In this review, we discuss the understanding of rafts that has emerged based on recent atomistic and coarse-grained molecular dynamics simulation studies on the key lipid raft components, which include cholesterol, sphingolipids, glycolipids, and the proteins interacting with these classes of lipids. The simulation results are compared to experiments when possible. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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