期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 165, 期 4, 页码 387-392出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2011.12.011
关键词
Liposomes; Structural characterization; Small-angle X-ray scattering; Poly(ethylene glycol); Sterical stabilization
资金
- Hungarian Scientific Research Fund (OTKA, Hungary)
- National Innovation Office (NIH, Hungary) [CNK-81056]
- European Community [226716]
Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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