期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 163, 期 8, 页码 787-793出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2010.09.004
关键词
Liposome mechanics; Evans model; Aspiration; DOPC:DOPS
资金
- National Science Foundation
- Keck Foundation Institute of Attofluidics at Drexel University
Quantification of the mechanical properties of liposomes is critical in helping to predict their behavior during various applications such as targeted drug delivery, response to mechanical characterization or their interactions with isolated cytoskeletal elements. A numerical implementation of the Evans aspiration technique, and an image processing algorithm for measuring deformation of spherical DOPC:DOPS liposomes is presented. Liposomes were aspirated to pressures of -10 mmHg (similar to-1300 Pa). The area expansion and Young's moduli of the liposomes were found to be 0.067 N m(-1) (67 +/- 4 dyn/cm) and 15 +/- 1 MPa, (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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