期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 154, 期 2, 页码 87-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2008.05.002
关键词
bile salt; solubilization; cholesterol; sitostanol; micelle
We investigated the difference between the molecular structures of plant sterols and stanols that affect the solubilization of cholesterol in bile salt micelles (in vitro study). First, the aqueous solubility of beta-sitosterol, beta-sitostanol, and campesterol was determined by considering the specific radioactivity by using a fairly small quantity of each radiolabeled compound. The order of their aqueous solubilities was as follows: cholesterol > campesterol > beta-sitostanol > beta-sitosterol. The maximum solubility of cholesterol and the above mentioned sterol/stanol in sodium taurodeoxycholate and sodium taurocholate solutions (single solubilizate system) was measured. Moreover, the preferential solubilization of cholesterol in bile salt solutions was systematically studied by using different types of plant sterols/stanols. The solubilization results showed that the cholesterol-lowering effect was similar for sterols and stanol. Thermodynamic analysis was applied to these experimental results. The Gibbs energy change (Delta G degrees) for the solubilization of plant sterols/stanols showed a negative value larger than that for cholesterol. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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