期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 22, 页码 6567-6570出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411615
关键词
antitumor agents; cellular uptake; gold; nanoparticles; zwitterionic ligands
资金
- NIH [EB014277]
- Japan Society for the Promotion of Sciences
A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH7.4, becoming positively charged at tumorpH (<6.5). The particle uptake and cytotoxicity increase over this pHrange. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
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