期刊
CHEMISTRY & BIOLOGY
卷 20, 期 8, 页码 1033-1043出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2013.06.015
关键词
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资金
- Academy of Finland [118637, 258827, 259505]
- Helsinki University [788/51/2010]
- Office of Science of the US Department of Energy [DE-AC02-05CH11231]
- Academy of Finland (AKA) [258827, 259505, 259505, 258827] Funding Source: Academy of Finland (AKA)
Ribosomal peptides are produced through the posttranslational modification of short precursor peptides. Cyanobactins are a growing family of cyclic ribosomal peptides produced by cyanobacteria. However, a broad systematic survey of the genetic capacity to produce cyanobactins is lacking. Here we report the identification of 31 cyanobactin gene clusters from 126 genomes of cyanobacteria. Genome mining suggested a complex evolutionary history defined by horizontal gene transfer and rapid diversification of precursor genes. Extensive chemical analyses demonstrated that some cyanobacteria produce short linear cyanobactins with a chain length ranging from three to five amino acids. The linear peptides were N-prenylated and O-methylated on the N and C termini, respectively, and named aeruginosamide and viridisamide. These findings broaden the structural diversity of the cyanobactin family to include highly modified linear peptides with rare posttranslational modifications.
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