期刊
CHEMISTRY & BIOLOGY
卷 20, 期 5, 页码 629-635出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2013.03.018
关键词
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资金
- National Human Genome Research Institute/NIH [U41 HG003751]
- European Union [LSHG-CT-2005-518254 ENFIN]
Pathway databases are a means to systematically associate proteins with their functions and link them into networks that describe the reaction space of an organism. Here, the Reactome Knowledgebase provides a convenient example to illustrate strategies used to assemble such a reaction space based on manually curated experimental data, approaches to semiautomated extension of these manual annotations to infer annotations for a large fraction of a species' proteins, and the use of networks of functional annotations to infer pathway relationships among variant proteins that have been associated with disease risk through genome-wide surveys and resequencing studies of tumors.
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