Epigenetics Gets Sweeter: O-GlcNAc Joins the Histone Code

O-GlcNAcylation has now been added to the growing list of histone modifications making up the multifaceted histone-code (Sakabe et al., 2010). The sites of O-GlcNAc-histone modification hint at a role in chromatin remodeling, thus adding to mounting evidence that O-GlcNAc cycling sits atop a robust regulatory network maintaining higher-order chromatin structure and epigenetic memory.