期刊
CHEMISTRY & BIODIVERSITY
卷 11, 期 6, 页码 962-969出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201300365
关键词
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资金
- Basic Research Program of National Research Foundation - Ministry of Education, Science, and Technology [2012R1A1B3000603]
- Ministry of Health Welfare [HI12C1006]
- National Research Foundation of Korea [2012R1A1B3000603] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Antofine (ANTF) is a phenanthroindolizidine alkaloid isolated from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae), which is used as an herbal remedy for pain and inflammation. ANTF also possesses antiviral and antitumorigenic activities. In this study, we investigated the role of ANTF in adipogenesis. Chronic ABTF administration suppressed adipocyte differentiation and marker expression in a dose-dependent manner. Furthermore, acute administration of ANTF at early stages of differentiation process inhibited lipid droplet formation and adipogenic gene expression. ANTF Treatment decreased expression of PPAR gamma protein, a master transcription factor in the regulation of adipocyte differentiation, leading to a suppression of aP2 promoter activity. These results suggest that ANTF exerts potent anti-adipogenic effects via direct suppression of PPAR gamma protein expression, with consequent downregulation of adipogenic gene expression.
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