期刊
CHEMISTRY & BIODIVERSITY
卷 11, 期 9, 页码 1374-1380出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201300392
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资金
- National Science Council of the Republic of China [NSC 95-2320-B-127-001-MY3, NSC 98-2320-B-127-001-MY3, NSC 101-2320-B-127-001-MY3]
- Zuoying Branch of Kaohsiung Armed Forces General Hospital [ZAFGH 102-31]
Two new thymol (=5-methyl-2-(1-methylethyl) phenol) derivatives, 8,10-didehydro-9-(3-methylbutanoyl) thymol 3-O-tiglate (1) and 9-O-angeloyl-8-methoxythymol 3-O-isobutyrate (2), were isolated from the root of Eupatorium cannabinum ssp. asiaticum, together with six known compounds, 3-8. The structures of 1 and 2 were determined through extensive 1D/2D-NMR and MS analyses. Among the isolates, 9-acetoxy-8,10-epoxythymol 3-O-tiglate (3) was the most cytotoxic, with IC50 values of 0.02 +/- 0.01, 1.02 +/- 0.07, and 1.36 +/- 0.12 mu g/ml, respectively, against DLD-1, CCRF-CEM, and HL-60 cell lines. In addition, 10-acetoxy-9-O-angeloyl-8-hydroxythymol (4) and eupatobenzofuran (6) exhibited cytotoxicities, with IC50 values of 1.14 +/- 0.16 and 2.63 +/- 0.22, and 7.63 +/- 0.94 and 2.31 +/- 0.14 mu g/ml, respectively, against DLD-1 and CCRF-CEM cell lines.
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