期刊
CHEMISTRY & BIODIVERSITY
卷 10, 期 3, 页码 385-393出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100431
关键词
Sterol-polyamine conjugates; dimeric; Squalamine; Antibacterial activity; Polyamines
资金
- National Science Foundation [CHE-0345248]
- National Natural Science Foundation of China [21072090]
- Program for New Century Excellent Talents in University [NCET-11-0920]
- Department of Education of Guangdong Province, China
Four dimeric sterolpolyamine conjugates have been synthesized from the homo- and hetero-connection of monomeric sterolpolyamine analogs in a head-to-tail manner. These dimeric conjugates show strong antibacterial activity against a broad spectrum of Gram-positive bacteria, whereas their corresponding activities against Gram-negative bacteria are relatively moderate. Though no significant difference was observed in the activities of these conjugates, cholic acid-containing dimeric conjugates generally exhibit higher activities than the corresponding deoxycholic acid-derived analogs. This is in contrast to the finding that a monomeric deoxycholic acid-spermine conjugate was more active than the corresponding cholic acid-derived analog.
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