期刊
CHEMISTRY & BIODIVERSITY
卷 9, 期 8, 页码 1517-1524出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100272
关键词
Triterpenes; Leishmanicidal activity; Anticandidal activity; Astraeus hygrometricus; Fungi; X-Ray crystallography
Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, 1H- and 13C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity.
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