Isolation and Neuroprotective Activities of Acylated Iridoids from Valeriana jatamansi

Three new iridoids, jatairidoids AC (13, resp.), have been isolated from the roots of Valeriana jatamansi (V. wallichii). Their structures were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR). Compounds 1 and 2 are C(3)-epimers. The three compounds were evaluated for their neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. All the isolates exhibited moderate neuroprotective effects.