期刊
CHEMISTRY & BIODIVERSITY
卷 8, 期 11, 页码 1968-1977出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100156
关键词
Natural product library; Dictionary of Natural Products; Drug discovery; Molecular diversity; Statistical analysis
资金
- National Basic Research Program of China [2010CB126100]
- National Natural Science Foundation of China [30870520, 21075046]
- Fundamental Research Funds for the Central Universities
To evaluate the potential of natural products as novel structure suppliers, a historical analysis was performed on the structural novelty of a natural product library, viz., the Chapman & Hall/CRC Dictionary of Natural Products. The results show that although the unexplored natural product universe is still ample, it is more and more difficult to find novel agents from nature, with the discovery probability of novel structures and scaffolds being lower than 50% in the near future, which mainly results from the intrinsic redundancy of natural products and, thus, is unlikely to be reversed merely through technical progresses.
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