New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus, Phialocephala sp., Strain FL30r

Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5 +/- 1.4, 0.1 +/- 0.1, and 0.2 +/- 0.01 mu M, resp.) and K562 (IC(50) values of 22.9 +/- 0.8, 4.8 +/- 0.3 and 22.4 +/- 0.9 mu M, resp.) cell lines.