期刊
CHEMISTRY & BIODIVERSITY
卷 8, 期 10, 页码 1908-1913出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201000247
关键词
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资金
- State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2008-ZZ22]
- Department of Science and Technology in Yunnan Province [20080A007]
- Natural Science Foundation of Yunnan [2008CD159]
Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4 alpha, 10 alpha-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-beta-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-beta-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
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