期刊
CHEMISTRY & BIODIVERSITY
卷 7, 期 3, 页码 536-542出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200900343
关键词
-
资金
- Nucleic Acid Center
- Danish National Research Foundation
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.
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