期刊
CHEMISTRY & BIODIVERSITY
卷 6, 期 4, 页码 520-526出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200800224
关键词
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资金
- Nagano Techno Foundation
A concise synthesis of (-)-epicatechin 3-(3-O-methylgallate) (1; ECG3Me), which is a minor constituent of tea, and (+)-catechin 3-(3-O-methylgallate) (2; CG3Me) via condensation of equimolar amount of catechin and gallate derivatives has been achieved. The anti-inflammatory effect of the synthetic compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears was examined. Compounds I and 2 suppressed the TPA-induced inflammation of mouse ears by 50 and 43%, respectively, at a dose of 200 mu g. Their activities are stronger than those of indomethacin and glycyrrhetinic acid, the normally used anti-inflammatory agents.
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