Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors Part 13. Synthesis of Fluorine-Containing Diaryltriazine Derivatives for in vitro Anti-HIV Evaluation against Wild-Type Strain

A series of diaryltriazine derivatives modified at C(2) of the triazine ring with a fluorinated phenyl group has been synthesized and tested for the ability to inhibit HIV-1 replication. Most of these F-containing compounds showed low-to-moderate anti-HIV activity in MT-4 cells.