Sesquiterpene glucosides from Chloranthus japonicus SIEB.

A new lindenane sesquiterpene glucoside named yinxiancaoside A(1), a new, rare bidesmosidic megastigmane sequiterpene glucoside named yinxiancaoside B(5), and three known sesquiterpene glucosides, chloranoside A(2), posumionoside (3), and sarcaglaboside A (4), were isolated from the whole plant of Chloranthus japonicus SIEB. The structures of the new compounds were estabalished by an extensive study of their spectral data, especially 1D- and 2D-NMR. The cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), human ovarian carcinoma (OV420) and human breast cancer (MCF-7) cells was investigated.