期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 210, 期 -, 页码 96-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2014.01.003
关键词
Concanavalin A (Con A); Autophagy; PI3K/Akt/mTOR pathway; MEK/ERK pathway
资金
- Council of Scientific & Industrial Research, India
- Department of Biotechnology, Govt. of India
Concanavalin A (Con A), a mannose or glucose specific legume lectin, is well known for its anti-proliferative and cytotoxic died on different types of cancer cells, through its binding to the membrane receptors leading to a major stimulus for the induction of distinct metabolic responses. Recently it has been also been proved that, Con A induces autophagy in hepatoma cells through internalization and mitochondria mediated pathway involving a mitochondrial interacting protein named Bc12/E1B-19 kDa proteininteracting protein 3 (BNIP3). Through this current endeavor, we propose a membrane associated pathway involved in Con A induced autophagy, taking Human cervical cancer (HeLa) cell as a cancer model. Here, we deciphered the role of membrane mediated phosphatidylinositol 3 kinase (PI3K)/Akt/mTOR (mammalian target of rapamycin) and MEK/Extracellular signal-regulated kinases (ERK) pathway in Con A induced autophagy in HeLa cells. Subsequently, we found that Con A treatment suppresses the PI3K/Akt/mTOR and up regulates the MEK/ERK pathway leading to the activation of autophagy. This study will further help us to understand the mechanism behind the autophagic pathway induced by Con A and simultaneously it will strengthen its effective use as a prospective cancer chemo-therapeutic. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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