期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 224, 期 -, 页码 78-88出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2014.09.025
关键词
Morin; Gold nanoparticles; Nanoparticle internalization; Breast cancer; Apoptosis; Secondary necrosis
资金
- CSIR, India [ADD-CSC0302]
There is significant interest in investigating the therapeutic potential of phytochemical reduced and bound gold nanoparticles (AuNPs) as it bridges. the gap between nanotechnology and therapy. In the present study, AuNPs prepared using the fiavonoid morin (mAuNPs) are characterised and have been studied for their anti-cancer effects. The -OH groups of morin reduce Au3+ and stabilize Au-0 to form spherical and crystalline mAuNPs. These mAuNPs are biocompatible towards normal human blood cells and breast epithelial cells. Through TEM analysis, we report that they are readily taken up by breast cancer cells (MCF-7) to induce cell death. Apoptosis has also been assessed by other morphological observations and cell viability studies. Flow cytometric studies reveal that the cells undergo a transient phase of apoptosis progressing towards secondary necrosis as the dose and time of mAuNPs treatment increases. The ability of mAuNPs to induce cell death in MCF-7 cells indicates its potential as an anti-cancer agent. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据