期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 188, 期 2, 页码 289-300出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2010.06.003
关键词
Apoptosis; ROS; Oxidative stress; Neurodegeneration; Environmental; Toxicants
资金
- National Institutes of Health [P20RR17675]
- Centers of Biomedical Research Excellence (COBRE)
- University of Nebraska Foundation
- University of Nebraska
- School of Community Health Sciences
- University of Nevada-Reno
Pesticides are widely used in agricultural and other settings, resulting in continued human exposure. Pesticide toxicity has been clearly demonstrated to alter a variety of neurological functions. Particularly, there is strong evidence suggesting that pesticide exposure predisposes to neurodegenerative diseases. Epidemiological data have suggested a relationship between pesticide exposure and brain neurodegeneration. However, an increasing debate has aroused regarding this issue. Paraquat is a highly toxic quaternary nitrogen herbicide which has been largely studied as a model for Parkinson's disease providing valuable insight into the molecular mechanisms involved in the toxic effects of pesticides and their role in the progression of neurodegenerative diseases. In this work, we review the molecular mechanisms involved in the neurotoxic action of pesticides, with emphasis on the mechanisms associated with the induction of neuronal cell death by paraquat as a model for Parkinsonian neurodegeneration. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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