期刊
CHEMICAL SOCIETY REVIEWS
卷 47, 期 20, 页码 7539-7551出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cs00735c
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资金
- U.S. Department of Energy, Office of Science, Basic Energy Sciences [DE-FG02-00ER45810]
- Center for Bio-Inspired Energy Science (CBES), a DOE [DE-SC0000989]
- National Institutes of Health (National Institute of Dental and Craniofacial Research) [R01 DE015920]
- National Institute of Biomedical Imaging and Bioengineering [R01 EB003806]
- National Heart, Lung, and Blood Institute [R01 HL116577, P01 HL108795]
- National Science Foundation [DMR-1508731]
- National Cancer Institute [F5U54CA151880]
- NATIONAL CANCER INSTITUTE [U54CA151880] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [PN1EY016569] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL108795, R01HL116577] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015920] Funding Source: NIH RePORTER
Supramolecular assembly of peptide-based monomers into nanostructures offers many promising applications in advanced therapies. In this Tutorial Review, we introduce molecular designs to control the structure and potential biological function of supramolecular assemblies. An emphasis is placed on peptide-based supramolecular nanostructures that are intentionally designed to signal cells, either directly through the incorporation of amino acid sequences that activate receptors or indirectly by recruiting native signals such as growth factors. Additionally, we describe the use and future potential of hierarchical structures, such as single molecules that assemble into nanoscale fibers which then align to form macroscopic strings; the strings can then serve as scaffolds for cell growth, proliferation, and differentiation.
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