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SCIENCE (2008)
Selective intracellular release of copper and zinc ions from bis( thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide
Paul S. Donnelly et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease:: a phase IIa, double-blind, randomised, placebo-controlled trial
Lars Lannfelt et al.
LANCET NEUROLOGY (2008)
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency
M. Stoltenberg et al.
NEUROSCIENCE (2007)
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS
Blaine R. Roberts et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands
Aphrodite Caragounis et al.
BIOCHEMICAL JOURNAL (2007)
Myelin breakdown and iron changes in Huntington's disease: Pathogenesis and treatment implications
George Bartzokis et al.
NEUROCHEMICAL RESEARCH (2007)
Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles
Johann M. Hagenah et al.
JOURNAL OF NEUROLOGY (2007)
Copper- and iron-induced differential fibril formation in α-synuclein:: TEM study
Bharathi et al.
NEUROSCIENCE LETTERS (2007)
Neurorescue activity, APP regulation and amyloid-β peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, m-30 and green tea polyphenol, EGCG
Yael Avramovich-Tirosh et al.
CURRENT ALZHEIMER RESEARCH (2007)
Redox reactions of copper complexes formed with different β-amyloid peptides and their neuropathalogical relevance
Dianlu Jiang et al.
BIOCHEMISTRY (2007)
The redox chemistry of the Alzheimer's disease amyloid β peptide
Danielle G. Smith et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
Susanne Petri et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Individual dopaminergic neurons show raised iron levels in Parkinson disease
A. E. Oakley et al.
NEUROLOGY (2007)
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis
Shohei Watanabe et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
Katherine J. Schweitzer et al.
JOURNAL OF NEUROLOGY (2007)
Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy
Evandro Ferrada et al.
NEUROTOXICOLOGY (2007)
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting β-amyloid burden
Tarja M. Malm et al.
JOURNAL OF NEUROSCIENCE (2007)
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology
Marjatta Son et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor
Claudio Acuna-Castillo et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Mechanisms of Copper Ion Mediated Huntington's Disease Progression
Jonathan H. Fox et al.
PLOS ONE (2007)
Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-β peptide
David P. Smith et al.
BIOCHEMISTRY (2007)
Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
George Bartzokis et al.
NEUROBIOLOGY OF AGING (2007)
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis
Rajaa El Meskini et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2007)
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein
David R. Taylor et al.
BIOCHEMICAL JOURNAL (2007)
How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?
Bryan F. Shaw et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis
Eiichi Tokuda et al.
TOXICOLOGY (2007)
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Toni Ahtoniemi et al.
MOLECULAR PHARMACOLOGY (2007)
Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease
Yael Avramovich-Tirosh et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Combating Alzheimer's disease with multifunctional molecules designed for metal passivation
Harvey Schugar et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes
Joseph Rogers et al.
NEUROBIOLOGY OF AGING (2006)
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity
Michelle L. Schlief et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
Dagmar E. Ehrnhoefer et al.
HUMAN MOLECULAR GENETICS (2006)
Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons
Zhi-Dian Niu et al.
TOXICOLOGY LETTERS (2006)
Elevated cortical zinc in Alzheimer disease
D. Religa et al.
NEUROLOGY (2006)
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer's disease
Lisa M. Miller et al.
JOURNAL OF STRUCTURAL BIOLOGY (2006)
A role for zinc in postsynaptic density asSAMbly and plasticity?
Eckart D. Gundelfinger et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration
Christopher J. Frederickson et al.
JOURNAL OF NEUROSCIENCE METHODS (2006)
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice:: Implications for Alzheimer β-amyloid pathology
Christa J. Maynard et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Amyloid β and neuromelanin -: Toxic or protective molecules?: The cellular context makes the difference
K. S. J. Rao et al.
PROGRESS IN NEUROBIOLOGY (2006)
Overexpression of Aβ is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model
QX Li et al.
AGING CELL (2006)
An architectural framework that may lie at the core of the postsynaptic density
MK Baron et al.
SCIENCE (2006)
4-hydroxynonenal disrupts zinc export in primary rat cortical cells
JL Smith et al.
NEUROTOXICOLOGY (2006)
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease
A Takeda et al.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2006)
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice
CR Jack et al.
JOURNAL OF NEUROSCIENCE (2005)
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases:: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition
H Zheng et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation
RA Lorca et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion
S Gal et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CAI neurons
ZD Niu et al.
NEUROREPORT (2005)
Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
EF Goodall et al.
NEUROLOGY (2005)
Alzheimer disease β-amyloid activity mimics cholesterol oxidase
L Puglielli et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model
T Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse
J Qian et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques
M Stoltenberg et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2005)
Metals and amyloid-β in Alzheimer's disease
CJ Maynard et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2005)
The neurobiology of zinc in health and disease
CJ Frederickson et al.
NATURE REVIEWS NEUROSCIENCE (2005)
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
B Angeletti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide
TJ Nelson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease
MA Lovell et al.
NEUROTOXICITY RESEARCH (2005)
Histological co-localization of iron in Aβ plaques of PS/APP transgenic mice
MF Falangola et al.
NEUROCHEMICAL RESEARCH (2005)
Zinc-specific autometallographic in vivo selenium methods: Tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells
G Danscher et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)
NMDA receptor activation mediates copper homeostasis in hippocampal neurons
ML Schlief et al.
JOURNAL OF NEUROSCIENCE (2005)
Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease
KJH Robson et al.
JOURNAL OF MEDICAL GENETICS (2004)
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
AL Friedlich et al.
JOURNAL OF NEUROSCIENCE (2004)
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
JY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Neurodegenerative diseases and oxidative stress
KJ Barnham et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β
CS Atwood et al.
BIOCHEMISTRY (2004)
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis
M Kiaei et al.
JOURNAL OF NEUROSCIENCE (2004)
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Aβ peptides
XD Huang et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2004)
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation
YM Zhang et al.
JOURNAL OF NEUROSCIENCE (2004)
The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice
JY Lee et al.
NEUROBIOLOGY OF AGING (2004)
Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases
MBH Youdim et al.
JOURNAL OF NEURAL TRANSMISSION (2004)
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-β precursor protein gene
SA Bellingham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
SA Bellingham et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
TA Bayer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
In vivo reduction of amyloid-β by a mutant copper transporter
AL Phinney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
KJ Barnham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Methods for studying synaptosomal copper release
A Hopt et al.
JOURNAL OF NEUROSCIENCE METHODS (2003)
Trace amounts of copper in water induce b-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
DL Sparks et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Iron-binding characteristics of neuromelanin of the human substantia nigra
KL Double et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors
C Coddou et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Red cell perturbations by amyloid β-protein
R Jayakumar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2003)
The metallobiology of Alzheimer's disease
AI Bush
TRENDS IN NEUROSCIENCES (2003)
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
D Kaur et al.
NEURON (2003)
Metal binding and oxidation of amyloid-β within isolated senile plaque cores:: Raman microscopic evidence
J Dong et al.
BIOCHEMISTRY (2003)
The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice
S Nagano et al.
EXPERIMENTAL NEUROLOGY (2003)
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A beta amyloid deposition and toxicity in Alzheimer disease - A pilot phase 2 clinical trial
CW Ritchie et al.
ARCHIVES OF NEUROLOGY (2003)
Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity
H Yamanishi et al.
CLINICAL CHEMISTRY (2003)
Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
CJ Maynard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
JT Rogers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Ccs knockout mice establish an alternative source of copper for SOD in ALS
JS Beckman et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Metalloenzyme-like activity of Alzheimer's disease β-amyloid -: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
C Opazo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Elevation of serum copper levels in Alzheimer's disease
R Squitti et al.
NEUROLOGY (2002)
Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
AI Bush
NATURE NEUROSCIENCE (2002)
Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging
Y Uchida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
JY Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Formation of camosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors
C Coddou et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species
EA Ostrakhovitch et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Redox processes of methionine relevant to β-amyloid oxidation and Alzheimer's disease
C Schöneich
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
D-penicillamine reduces serum oxidative stress in Alzheimer's disease patients
R Squitti et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2002)
Evidence of oxidative damage in Alzheimer's disease brain:: central role for amyloid β-peptide
DA Butterfield et al.
TRENDS IN MOLECULAR MEDICINE (2001)
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
CA Grimes et al.
PROGRESS IN NEUROBIOLOGY (2001)
New insights on how metals disrupt amyloid β-aggregation and their effects on amyloid-β cytotoxicity
Y Yoshiike et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
RA Cherny et al.
NEURON (2001)
New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals:: An ESR study using a series of spin-traps
S Turnbull et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages:: consequences for iron storage and neurodegenerative processes
L Zecca et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice
MJ Callahan et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)
Copper-64-diacetyl-bis(N4-methylthiosemicarbazone):: An agent for radiotherapy
JS Lewis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
α-Synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies
M Neumann et al.
ACTA NEUROPATHOLOGICA (2000)
Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release
E Aizenman et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Sequestration of iron by Lewy bodies in Parkinson's disease
RJ Castellani et al.
ACTA NEUROPATHOLOGICA (2000)
Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc
MP Cuajungco et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The actions of synaptically released zinc at hippocampal mossy fiber synapses
K Vogt et al.
NEURON (2000)
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
I Maurer et al.
NEUROBIOLOGY OF AGING (2000)
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
SW Suh et al.
BRAIN RESEARCH (2000)
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
LM Sayre et al.
JOURNAL OF NEUROCHEMISTRY (2000)
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