期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 12, 页码 5802-5814出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15049a
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资金
- Academy of Sciences of the Czech Republic [Z4 055 0506, Z5 004 0507, Z5 004 0702]
- Ministry of Education [LC06035, LC512]
- Grant Agency of the Academy of Sciences of the Czech Republic [IAA400040901]
- Czech Science Foundation [203/09/0317]
- Gilead Sciences, Inc. (Foster City, CA, USA)
Basic aspects of DNA electrochemistry with a strong focus on the use of modified nucleobases as redox probes for electrochemical bioanalysis are reviewed. Intrinsic electrochemical properties of nucleobases in combination with artificial redox-active nucleobase modifications are frequently applied in this field. Synthetic approaches (both chemical and enzymatic) to base-modified nucleic acids are briefly summarized and their applications in redox labelling are discussed. Finally, analytical applications including DNA hybridization, primer extension, PCR, SNP typing, DNA damage and DNA-protein interaction analysis are presented (critical review, 91 references).
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