期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 1, 页码 340-362出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b915149b
关键词
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资金
- NIH [CA 55791, CA 114053, CA-109914, CA 127369, CA 127369-02S1]
- Oishei Foundation
- Oncologic Foundation of Buffalo and Roswell Park Alliance Foundation
- The Mallinckrodt Medical Inc. St. Louis (USA)
- [CA-119358]
- NATIONAL CANCER INSTITUTE [R21CA114053, R33CA109914, R01CA119358, R01CA127369, R21CA109914, P30CA016056, P01CA055791] Funding Source: NIH RePORTER
In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references).
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