期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 7, 页码 3391-3404出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cs00180e
关键词
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资金
- Center for Nanostructured Materials Technology, Korean Ministry of Education, Science, and Technology [08K1501-01910]
- Mark Prautznitz and The Center for Drug Design, Development, and Delivery
- China Scholar Council [2008683010]
- U.S. National Institute of Health [1U01CA151802-01]
- NATIONAL CANCER INSTITUTE [U01CA151802] Funding Source: NIH RePORTER
Gold nanoparticles possess a unique combination of properties which allow them to act as highly multifunctional anti-cancer agents (X. H. Huang, P. K. Jain, I. H. El-Sayed and M. A. El-Sayed, Nanomedicine, 2007, 2, 681-693; P. Ghosh, G. Han, M. De, C. K. Kim and V. M. Rotello, Adv. Drug Delivery Rev., 2008, 60, 1307-1315; S. Lal, S. E. Clare and N. J. Halas, Acc. Chem. Res., 2008, 41, 1842-1851; D. A. Giljohann, D. S. Seferos, W. L. Daniel, M. D. Massich, P. C. Patel and C. A. Mirkin, Angew. Chem., Int. Ed., 2010, 49, 3280-3294). Not only can they be used as targeted contrast agents for photothermal cancer therapy, they can serve as scaffolds for increasingly potent cancer drug delivery, as transfection agents for selective gene therapy, and as intrinsic antineoplastic agents. This tutorial review will highlight some of the many forms and recent applications of these gold nanoparticle conjugates by our lab and others, as well as their rational design and physiologic interactions.
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