期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 5, 页码 2508-2524出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cs00114g
关键词
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资金
- National Natural Science Funds for Distinguished Young Scholars [20825101]
- National Natural Science Foundation of China [20775017, 91027004, 20804019, 50803028]
- Shanghai Sci. Tech. Comm. [1052nm03400, 10431903100]
- Shanghai Leading Academic Discipline Project [B108]
- CAS/SAFEA
- [IRT0911]
The application of phosphorescent heavy-metal complexes with d(6), d(8) and d(10) electron configurations for bioimaging is a new and promising research field and has been attracting increasing interest. In this critical review, we systematically evaluate the advantages of phosphorescent heavy-metal complexes as bioimaging probes, including their photophysical properties, cytotoxicity and cellular uptake mechanisms. The progress of research into the use of phosphorescent heavy-metal complexes for staining different compartments of cells, monitoring intracellular functional species, providing targeted bioimaging, two-photon bioimaging, small-animal bioimaging, multimodal bioimaging and time-resolved bioimaging is summarized. In addition, several possible future directions in this field are also discussed (133 references).
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