期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 5, 页码 3005-3018出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cs00215a
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资金
- National Health and Medical Research Council
- Australian Research Council
- Albert Shimmins Memorial Fund
The molecules known as bis(thiosemicarbazones) derived from 1,2-diones can act as tetradentate ligands for Cu(II), forming stable, neutral complexes. As a family, these complexes possess fascinating biological activity. This critical review presents an historical perspective of their progression from potential chemotherapeutics through to more recent applications in nuclear medicine. Methods of synthesis are presented followed by studies focusing on their potential application as anti-cancer agents and more recent investigations into their potential as therapeutics for Alzheimer's disease. The Cu(II) complexes are of sufficient stability to be used to coordinate copper radioisotopes for application in diagnostic and therapeutic radiopharmaceuticals. Detailed understanding of the coordination chemistry has allowed careful manipulation of the metal based properties to engineer specific biological activities. Perhaps the most promising complex radiolabelled with copper radioisotopes to date is Cu-II(atsm), which has progressed to clinical trials in humans (162 references).
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