期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 4, 页码 1870-1874出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cs00165a
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资金
- NIGMS NIH HHS [R01 GM050781] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050781] Funding Source: NIH RePORTER
The functionalization of C-H bonds has yet to achieve widespread use in synthetic chemistry in part because of the lack of synthetic reagents that function in the presence of other functional groups. These problems have been overcome in enzymes, which have metal-oxo active sites that efficiently and selectively cleave C-H bonds. How high-energy metal-oxo transient species can perform such difficult transformations with high fidelity is discussed in this tutorial review. Highlighted are the relationships between redox potentials and metal-oxo basicity on C-H bond activation, as seen in a series of bioinspired manganese-oxo complexes.
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