期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 12, 页码 5669-5679出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15027h
关键词
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The complementary Watson-Crick base-pairs, A:T and G:C, have long been recognized as pivotal to both the stability of the DNA double helix and replication/transcription. Recently, the replacement of the Watson-Crick base-pairs with other molecular entities has received considerable attention. In this tutorial review we highlight different approaches used to replace natural base-pairs and equip them with novel function. We also discuss the advantages that non-natural base-pairs convey with respect to practical applications.
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