期刊
CHEMICAL SOCIETY REVIEWS
卷 40, 期 12, 页码 5910-5921出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15212b
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资金
- Deutsche Forschungsgemeinschaft (DFG)
- Bundesministerium fur Bildung und Forschung (BMBF)
- Alexander-von-Humboldt Stiftung
- European Union
- Max-Planck Society
Proteins possess intrinsic functionalities, which have been optimized in billions of years of natural evolution. The conjugation of proteins with artificial nucleic acids allows one to further functionalize proteins with a synthetically accessible, physicochemically robust tag, which is addressable in a highly specific manner by Watson-Crick hybridization. The resulting DNA-protein conjugates can be advantageously used in a variety of applications, ranging from biomedical diagnostics to DNA-based nanofabrication. This critical review provides an overview on chemical approaches to the synthesis of DNA-protein conjugates and their applications in biomolecular nanosciences (96 references).
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