期刊
CHEMICAL SOCIETY REVIEWS
卷 39, 期 4, 页码 1272-1279出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b901970g
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059907, R37GM058867] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM059907-10, R01 GM059907, R37 GM058867] Funding Source: Medline
Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems-in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.
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