期刊
CHEMICAL SOCIETY REVIEWS
卷 39, 期 9, 页码 3480-3498出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b915923c
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资金
- Engineering and Physical Sciences Research Council (EPSRC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Royal Society
- Chinese National Key Lab of Heavy Oil Processing and National Natural Science Foundation of China [20773164]
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
- National Science Foundation [CCR-0122419]
- NIH BRP [EB003805]
- ROHM Ltd.
- Menicon Co. Ltd, Mitsui Chemicals, Inc.
- Mitsubishi Chemicals Corp.
- Intel Corp.
- John Simon Guggenheim Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003805] Funding Source: NIH RePORTER
Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies. Apart from sizes, the primary sequences of short peptides are very diverse as they can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and the nanostructures also vary enormously. This critical review highlights recent advances in studying peptide amphiphiles, focusing on the formation of different nanostructures and their applications in diverse fields. Many interesting features learned from peptide self-organisation and hierarchical templating will serve as useful guidance for functional materials design and nanobiotechnology (123 references).
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