期刊
CHEMICAL SENSES
卷 38, 期 2, 页码 137-145出版社
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjs090
关键词
ENaC; general labeled magnitude scales; genotype; salt taste; suprathreshold; TRPV1
资金
- Advanced Foods and Materials Network (AFMNet)
- Natural Sciences and Engineering Research Council
The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in the SCNN1A (3), SCNN1B (12), SCNN1G (6), and TRPV1 (10) genes affect salt taste perception. Participants were men (n 28) and women (n 67) from the Toronto Nutrigenomics and Health study aged 2131 years. Taste thresholds were determined using a 3-alternative forced-choice staircase model with solutions ranging from 910(6) to 0.5mol/L. Suprathreshold taste sensitivity to 0.011.0mol/L salt solutions was assessed using general labeled magnitude scales. None of the SNPs in the SCNN1A and SCNN1G genes were significantly associated with either outcome. In the SCNN1B gene, 2 SNPs in intronic regions of the gene modified suprathreshold taste sensitivity (mean iAUC SE). Those homozygous for the A allele of the rs239345 (A > T) polymorphism and the T allele of the rs3785368 (C > T) polymorphism perceived salt solutions less intensely than carriers of the T or C alleles, respectively (rs239345: 70.8212.16 vs. 96.953.75, P 0.02; rs3785368: 57.4319.85 vs. 95.573.66, P 0.03) In the TRPV1 gene, the rs8065080 (C > T, Val585Ile) polymorphism modified suprathreshold taste sensitivity where carriers of the T allele were significantly more sensitive to salt solutions than the CC genotype (98.33.8 vs. 74.18.3, P 0.008). Our findings show that variation in the TRPV1 and the SCNN1B genes may modify salt taste perception in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据