期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 31, 期 9, 页码 836-838出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.8b00155
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资金
- University of Minnesota Masonic Cancer pilot program
- University of Florida Medicinal Chemistry Mass Spectrometry Support
- College of Pharmacy Frank Duckworth Endowment
- University of Florida Health Cancer Center Startup fund
- [R01CA193286]
- NATIONAL CANCER INSTITUTE [R01CA193278] Funding Source: NIH RePORTER
Human urinary DNA adducts may be useful surrogate biomarkers to estimate carcinogen exposure and activation, particularly if such adducts are of high selectivity from a specific carcinogen source. In this report, we provided evidence supporting tobacco use and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) being the dominant source for 3-methyladenine (3-mA), while nontobacco factors contribute significantly to 7-methylguanine and 1-methyladenine in the urine. Upon confirmation in human urine samples from larger populations in the future, urinary 3-mA may be used to estimate NNK bioactivation in smokers and to facilitate the development of a chemopreventive agent against NNK-induced carcinogenesis.
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