期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 27, 期 2, 页码 172-174出版社
AMER CHEMICAL SOC
DOI: 10.1021/tx400454z
关键词
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资金
- MIT Center for Environmental Health Sciences through NIEHS [P30 ES002109]
- UNC Center for Environmental Health and Susceptibility by NIEHS [P30 ES010126]
- UGA
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
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