期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 25, 期 4, 页码 850-861出版社
AMER CHEMICAL SOC
DOI: 10.1021/tx2004294
关键词
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资金
- Regione Piemonte [CIPE 2006]
- Compagnia di San Paolo, Torino, Italy
Three hematite samples were synthesized by precipitation from a FeCl3 solution under controlled pH and temperature conditions in different morphology and dimensions: (i) microsized (average diameter 1.2 mu m); (ii) sub-microsized (250 run); and (iii) nanosized (90 nm). To gain insight into reactions potentially occurring in vivo at the particle-lung interface following dust inhalation, several physicochemical features relevant to pathogenicity were measured (free radical generation in cell-free tests, metal release, and antioxidant depletion), and cellular toxicity assays on human lung epithelial cells (A549) and murine alveolar macrophages (MH-S) were carried out (LDH release, apoptosis detection, DNA damage, and nitric oxide synthesis). The decrease in particles size, from 1.2 mu m to 90 nm, only caused a slight increase in structural defects (disorder of the hematite phase and the presence of surface ferrous ions) without enhancing surface reactivity or cellular responses in the concentration range between 20 and 100 mu g cm(-2).
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