期刊
CHEMICAL RECORD
卷 14, 期 1, 页码 101-116出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201300021
关键词
cycloaddition; isocyanides; multicomponent reactions; Passerini reaction; Ugi reaction
资金
- Japan Society for the Promotion of Science [20850017, 24750037, 24350022]
- Grants-in-Aid for Scientific Research [20850017, 24750037, 25620028] Funding Source: KAKEN
In order to develop a practical method for the construction of drug-like and heterocyclic compounds, we have designed a novel Passerini- or Ugi-type reaction system where a compound (which we write in the general form as Z-X) composed of an electrophilic (Z) and a nucleophilic group (X) could essentially perform the same function as the carboxylic acid. Based on this concept, we have developed the O-silylative Passerini reaction and the borinic acid catalyzed -addition of isocyanides to aldehydes and water. In addition, we have designed and demonstrated the addition reaction of isocyanides to nitrones in the presence of TMSCl to afford the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxyamides. Furthermore, a novel [5+1] cycloaddition of isocyanide was explored with C,N-cyclic N-acyl azomethine imines as a 1,5-dipole via a strategy involving intramolecular trapping of the isocyanide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据