期刊
CHEMICAL RECORD
卷 14, 期 1, 页码 41-51出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201300023
关键词
artificial oligonucleotides; click chemistry; DNA; reverse transcription; RNA
资金
- KAKENHI [20108015, 23550041, 24241036]
- Grants-in-Aid for Scientific Research [23550041] Funding Source: KAKEN
Click chemistry has provided us with access to DNA and RNA analogues with non-natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non-cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole-linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.
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