期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 25, 页码 7410-7413出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502324
关键词
arylation; barbituric acid; carbenes; diazo compounds; rhodium
资金
- ERC [258580]
- EPSRC
- European Research Council (ERC) [258580] Funding Source: European Research Council (ERC)
- Engineering and Physical Sciences Research Council [EP/I004769/1, EP/I004769/2] Funding Source: researchfish
- EPSRC [EP/I004769/1, EP/I004769/2] Funding Source: UKRI
A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free N-H groups are tolerated on the barbituric acid, with no complications arising from N-H insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.
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