期刊
CHEMICAL PHYSICS
卷 419, 期 -, 页码 17-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chemphys.2012.10.003
关键词
Cyclodextrin; Protonated molecule; Forensic science; Drug identification
资金
- MEXT, Japan [22018001, 19056008]
- JSPS, Japan [24241041]
- Grants-in-Aid for Scientific Research [23245029, 24550030, 19056008, 21108002, 22018001] Funding Source: KAKEN
A mass measurement technique for detecting low-molecular-weight drugs with a cyclodextrin-supported organic matrix was investigated. By using cyclodextrin-supported 2,4,6-trihydroxyacetophenone (THAP), the matrix-related peaks of drugs were suppressed. The peaks of protonated molecules of the sample and THAP were mainly observed, and small fragments were detected in a few cases. Despite the Na+ and K+ peaks were observed in the spectrum, Na+ or K+ adduct sample molecules were undetected, owing to the sugar units of cyclodextrin. The advantages of MALDI-MS with cyclodextrin-supported matrices as an analytical tool for forensic samples are discussed. The suppression of alkali adducted molecules and desorption process are also discussed. (C) 2012 Elsevier B.V. All rights reserved.
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