期刊
CHEMICAL ENGINEERING SCIENCE
卷 103, 期 -, 页码 58-67出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2012.12.023
关键词
Polyhydroxyalkanoate; Synthetic biology; Bioplastic; Metabolism; Biotechnology; Sustainability
资金
- Wisconsin Alumni Research Foundation
- National Science Foundation [CBET-1149678]
- DOE Great Lakes Bioenergy Research Center (DOE BER Office of Sciences) [DE-FC02-07ER64494]
- National Institutes of Health [NIH 5 T32 GM08349]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1149678] Funding Source: National Science Foundation
Discovered in the 1920s, polyhydroxyalkanoates (PHA) are a naturally occurring class of biopolyesters that have long been touted as a renewable, biodegradable plastic alternative. Demand for sustainable products and over a half century of research have led to moderate commercial success of PHA. Yet, these materials are not pervasive. Therefore, an important question to address is, what is the barrier that prevents widespread application of these materials? PHA can be made from an incredibly diverse class of monomers that incorporate both simple and complex organic acids. Herein, we provide an updated list of unique PHA monomers that are substrates for a PHA polymerase. Unfortunately, most unique monomers are incorporated only after feeding a structurally related feedstock to a PHA accumulating bacterium. Therefore, we put forward an argument that research must nosy turn to developing feedstock-independent, synthetic pathways to produce an increased diversity of PHAs capable of competing with petroleum-derived plastics. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据