期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 37, 页码 10912-10916出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504805
关键词
CN activation; cyclocarbonylation; dearomatization; palladium; quinolizinones
资金
- Chinese Academy of Sciences
- National Natural Science Foundation of China [21222203, 21172226, 21133011]
A fundamentally novel approach to bioactive quinolizinones is based on the palladium-catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I-2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene-substituted allylamines into bioactive quinolizinones in good to excellent yields. This transformation represents the first dearomative carbonylation and is proposed to proceed by palladium-catalyzed CN bond activation, dearomatization, CO insertion, and a Heck reaction.
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