期刊
CHEMICAL ENGINEERING SCIENCE
卷 64, 期 14, 页码 3344-3351出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2009.04.016
关键词
Bulk video imaging; Metastable zone determination; Crystallization; Imaging; Pharmaceutical crystallization; Food crystallization; Instrumentation
资金
- Engineering and Physical Sciences Research Council (EPSRC), UK [EP/E022294/1]
- EPSRC [EP/E022294/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E022294/1] Funding Source: researchfish
The purpose of the paper is twofold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra-violet visible (UV/vis) spectroscopy. While the latter two sample the system in small volumes closely to the probe, the BVI approach monitors the entire or large parts of the crystallizer volume. The BVI method is proposed as a complementary noninvasive PAT tool and it is shown that it is able to detect the boundaries of the metastable zone with comparable or better performance than the FBRM and UV/vis probes. (C) 2009 Elsevier Ltd. All rights reserved.
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