期刊
CHEMICAL ENGINEERING JOURNAL
卷 137, 期 1, 页码 30-37出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2007.07.078
关键词
silica-based mesoporous materials; drug delivery systems
Mesoporous MCM-41 silica functionalized by 3-aminopropyltriethoxysilane grafting was studied as a potential carrier for controlled drug release, using ibuprofen as a test drug. For comparison, non-functionahzed MCM-41 was also investigated. For the purpose of testing the effect of carrier morphology on drug delivery rate, MCM-41 was prepared in the form of both, a powder consisting of irregularly shaped (and sized) particles and monodispersed spheres (490 to 770 nm in diameter). Amine-functionalized MCM-41 micro-spheres were found to show a significantly slower drug release rate than irregularly shaped powders, which should facilitate drug delivery control over a longer time period. (C) 2007 Elsevier B.V. All rights reserved.
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